Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV

Domínguez-Rojas J.; Caute-Lara J.; Caqui-Vilca P.; Cruz-Arpi M.; Martel-Ramírez C.; Quispe-Chipana M.; Sánchez-Rodríguez A.; Atamari-Anahui N. · Boletin Medico del Hospital Infantil de Mexico (2023) · DOI: 10.24875/bmhim.22000051

Resumen

Background: Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis. Case report: We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution. Conclusions: The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.

Instituciones: Universidad San Ignacio de Loyola