Hybrid Deep Learning Model for Improved Glaucoma Diagnostic Accuracy

Flores N.; La Rosa J.; Tuesta S.; Izquierdo L.; Henriquez M.; Mauricio D. · Information (Switzerland) (2025) · DOI: 10.3390/info16070593

Resumen

Glaucoma is an irreversible neurodegenerative disease that affects the optic nerve, leading to partial or complete vision loss. Early and accurate detection is crucial to prevent vision impairment, which necessitates the development of highly precise diagnostic tools. Deep learning (DL) has emerged as a promising approach for glaucoma diagnosis, where the model is trained on datasets of fundus images. To improve the detection accuracy, we propose a hybrid model for glaucoma detection that combines multiple DL models with two fine-tuning strategies and uses a majority voting scheme to determine the final prediction. In experiments, the hybrid model achieved a detection accuracy of 96.55%, a sensitivity of 98.84%, and a specificity of 94.32%. Integrating datasets was found to improve the performance compared to using them separately even with transfer learning. When compared to individual DL models, the hybrid model achieved a 20.69% improvement in accuracy compared to the best model when applied to a single dataset, a 13.22% improvement when applied with transfer learning across all datasets, and a 1.72% improvement when applied to all datasets. These results demonstrate the potential of hybrid DL models to detect glaucoma more accurately than individual models.

Instituciones: Universidad Nacional Mayor de San Marcos