HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

Loiseau C.; Brites D.; Reinhard M.; Zürcher K.; Borrell S.; Ballif M.; Fenner L.; Cox H.; Rutaihwa L.K.; Wilkinson R.J.; Yotebieng M.; Jane Carter E.; Abimiku A.; Marcy O.; Gotuzzo E.; Avihingsanon A.; Zetola N.; Doulla B.; Böttger E.C.; Egger M.; Gagneux S. · Antimicrobial Agents and Chemotherapy (2020) · DOI: 10.1128/aac.00782-20

Resumen

We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. Copyright

Instituciones: Universidad Peruana Cayetano Heredia