Hematological biomarkers as predictors of mortality in hemodialysis patients
Ruiz-Suarez S.M.; Chávez-Bustamante S.G.; Cerron-Ventocilla K.J.; Arellan-Bravo L. · Revista Colombiana de Nefrologia (2026) · DOI: 10.22265/acnef.13.2.1015
Resumen
Introduction: Patients undergoing hemodialysis have a high mortality rate, highlighting the importance of identifying factors associated with clinical deterioration. Recent studies emphasize the use of costeffective hematological biomarkers as predictors of complications and mortality in various diseases. Objective: To evaluate the usefulness of hematological biomarkers as predictors of mortality in patients with chronic kidney disease undergoing hemodialysis. Materials and methods: A non-experimental, retrospective, observational, correlational, and crosssectional study was conducted. A total of 172 medical records of hemodialysis patients were analyzed, selected according to inclusion and exclusion criteria. Results: The overall mortality rate was 32.9 %. Bivariate analysis identified multiple factors significantly associated with mortality, including age over 65 years, origin outside Huancayo, diabetes mellitus as the cause of chronic kidney disease, presence of heart disease, neurological involvement, use of a temporary catheter as vascular access, obesity, hypoalbuminemia, and elevated platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios. The platelet-to-lymphocyte ratio showed a significant association (p = 0.007; 95 % CI: 1216-2338), as did hypoalbuminemia ≤3.5 g/dl (p < 0.001). Conclusions: Advanced age, origin outside Huancayo, diabetes mellitus as the cause of CKD, presence of heart disease and neurological involvement, use of temporary catheters, obesity, elevated platelet-tolymphocyte ratio, and hypoalbuminemia were significantly associated with increased mortality risk in patients at the initiation of hemodialysis treatment, constituting relevant clinical predictors for the early identification of high-risk patients.
Instituciones: Universidad Continental