Helicobacter pylori AND GENE EXPRESSION IN PATIENTS WITH GASTRIC ADENOCARCINOMA

Rabanal J. · Revista de la Facultad de Ciencias (2020) · DOI: 10.15446/rev.fac.cienc.v9n2.81923

Resumen

Gastric cancer (GC) has one of the highest incidences of cancer in the world. Several studies have associated the presence of a chronic infection with Helicobacter pylori, as a key process in the formation, growth and development of this cancer. Gastric adenocarcinoma is a subtype of CG and represents about 90% of reported cases. Many studies in patients with GC have reported the presence of mutations in genes that perform important functions in cell signaling, genomic integrity, cell adhesion, chromatin remodeling, cell motility and cytoskeletal formation. In this work we analyzed data from the cancer genome atlas (TCGA), from which we obtained data on the expression of these genes (expressed in transcripts per million); the median, value of the quartiles and the p-value of the difference of medians were obtained. This work found that many genes were overexpressed in gastric adenocarcinoma patients. However, some genes had an expression similar to that observed in non-cancerous conditions, when H. pylori infection was present; and these genes had overexpression in the absence of II. pylori. This study suggests that this should be due to DNA methylation produced by this bacterium, so this mechanism would inhibit the expression of these genes.

Instituciones: Universidad Peruana Cayetano Heredia