Granular Cell Tumor: A Rare Suprasellar Tumor

Dextre-Espinoza A.; Ildefonso-Najarro S.; Gonzales Chiroque F.B.; Vasquez Garcia E.E.E.; Fuentes-Mendoza J.M.; Concepción-Urteaga L.; Concepción-Zavaleta M. · Wisconsin Medical Journal (2026)

Resumen

Introduction: Granular cell tumors of the neurohypophysis are rare, benign neoplasms originat-ing from pituicytes that often pose diagnostic challenges due to their resemblance to other sellar lesions. Case Presentation: We report the case of a 26-year-old man with a 2-year history of headache, polyuria, and hypopituitarism. Magnetic resonance imaging revealed a 21 × 23×30 mm supra-sellar mass compressing the optic chiasm and hypothalamus. Hormonal evaluation showed hypogonadotropic hypogonadism, central hypothyroidism, and arginine vasopressin deficiency. The patient underwent partial tumor resection. Histopathology confirmed a grade I granular cell tumor, positive for thyroid transcription factor 1, S100, and vimentin. Discussion: Granular cell tumors are slow-growing lesions with nonspecific clinical and radio-logic features. Diagnosis relies on histologic and immunohistochemical findings. Complete resection is often limited by tumor vascularity and proximity to vital structures. Conclusions: Granular cell tumors should be considered in the differential diagnosis of supra-sellar tumors. Early recognition and multidisciplinary management may improve patient out-comes.

Instituciones: Universidad Nacional de Trujillo; Universidad Científica del Sur