Functions of LncRNAs, exosomes derived MSCs and immune regulatory molecules in preeclampsia disease

Al-Hawary S.I.S.; Tayyib N.A.; Ramaiah P.; Parra R.M.R.; Ibrahim A.J.; Mustafa Y.F.; Hussien B.M.; Alsulami S.A.; Baljon K.J.; Nomani I. · Pathology Research and Practice (2023) · DOI: 10.1016/j.prp.2023.154795

Resumen

Modulatory signaling pathway such as T cell immunoreceptor with Ig and ITIM domains (TIGIT), Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4), P53 signaling and TIM (T-cell immunoglobin and mucin domain) are important in normal pregnancy and loss of their functions or dysregulation of related genes can lead to some disorders. Inflammation is a process by which your body's white blood cells and the things they make protect you from infection from outside invaders, such as bacteria and viruses. Some cellular and molecular signaling have been categorized to demonstrate the mechanism that protects tolerance to antigens. lncRNAs significantly impact physiological processes like immunity and metabolism, and are linked to tumors, cardiovascular diseases, nervous system disorders, and nephropathy.In this review article, we summarized recent studies about the role of TIGIT, CTLA-4, P53 and TIM regulatory molecules and reviewed dysregulation of these pathway in diseases.We will also talk about the role of lncRNAs and mesenchymal stem cells.

Instituciones: Universidad Continental