Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis

Aldayyeni H.; Hjazi A.; Shahab S.; Gupta J.; Alsaab H.O.; Motea Y.H.; alazbjee A.A.A.; Romero-Parra R.M.; Obaid R.F.; Hussien B.M.; Hosseini-Fard S.R. · Human Cell (2023) · DOI: 10.1007/s13577-023-00936-0

Resumen

Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the biological processes via regulating epigenetics, transcription, and protein translation. A novel lncRNA, LINC00857, was indicated to upregulate in several types of cancer. In addition, LINC00857 was functionally related to the modulation of the cancer-linked behaviors, including invasion, migration, proliferation, epithelial–mesenchymal transition (EMT), cell cycle, and apoptosis. The importance of LINC00857 in cancer onset and development proposed that LINC00857 has major importance in the cancer progression and may be considered as a novel prognostic/diagnostic biomarker as well as a treatment target. Here, we retrospectively investigate the available progress in biomedical research investigating the functions of LINC00857 in cancer, focusing on finding the molecular mechanisms affecting various cancer-related behaviors and exploring its clinical applications.

Instituciones: Universidad Continental