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Fasciolicidal efficacy comparison between Amaro (Chuquiraga weberbaueri) and triclabendazole in calves experimentally infected with Fasciola hepatica metacercaria

Chávez V.; Vargas-Rocha L.; Rojas-Moncada J.; Torrel T. · Journal of the Hellenic Veterinary Medical Society (2025) · DOI: 10.12681/jhvms.37150

Resumen

The Cajamarca valley is an endemic area for cattle affected by Fasciola hepatica. Despite demonstrated resistance to triclabendazole, the use of this anthelmintic remains prevalent. Therefore, constant efficacy evaluations of this active ingredient and exploring alternatives for parasite control are necessary. This study aimed to determine the effectiveness of Amaro (Chuquiraga weberbaueri) and triclabendazole in controlling F. hepatica in experimentally infected calves. Three groups (T0, T1, and T2) of four weaned Holstein calves each were formed and infected with 200 metacercaria. The control group (T0) received no antiparasitic treatment, group T1 was dosed with lyophilized aqueous extract of C. weberbaueri (200 mg.kg-1, orally, for four consecutive days), and group T2 received a single dose of triclabendazole (12 mg.kg-1, orally). Clinical efficacy was assessed using the Egg Count Reduction Test, and absolute efficacy was determined by adult parasite counts at necropsy. The mean clinical efficacy of C. weberbaueri was 46.70% (95% CI: 33.27 - 60.13) and of triclabendazole 25.00 (95% CI: 12.62 - 37.38) (p=0.029). The efficacies increased in the count of adult parasites at necropsy but were not statistically different (p=0.686), C. weberbaueri showed an efficacy of 58.63% (95% CI: 45.24 - 72.02), and triclabendazole 66.22% (95% CI: 53.36 - 79.08). Both treatments proved insufficiently active against F. hepatica in calves, falling short of the category of effective fasciolicides. Nevertheless, using C. weberbaueri could be considered an environmentally friendly option to reduce the parasite burden in cattle. © (2025), (Hellenic Veterinary Medical Society). All rights reserved.

Instituciones: Universidad Nacional de Cajamarca