Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis

Rossi N.M.; Dai J.; Xie Y.; Wangsa D.; Heselmeyer-Haddad K.; Lou H.; Boland J.F.; Yeager M.; Orozco R.; Freites E.A.; Mirabello L.; Gharzouzi E.; Dean M. · Cancer research (2023) · DOI: 10.1158/0008-5472.can-22-3030

Resumen

SIGNIFICANCE: Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.

Instituciones: Universidad para el Desarrollo Andino