Evaluation of cerebral and hepatic oxidative metabolism by administration of risperidone in a subacute model in rats (Rattus norvegicus); [Avaliação do metabolismo oxidativo cerebral e hepático utilizando risperidona em um modelo subagudo em ratos (Rattus norvegicus)]

Salcedo-Valdez L.; Suárez-Cunza S. · Revista Colombiana de Ciencias Quimico-Farmaceuticas (Colombia) (2026) · DOI: 10.15446/rcciquifa.v55n2.122376

Resumen

Objectives: this study aimed to evaluate the impact of subacute risperidone administration on antioxidant enzyme activity and lipid peroxidation in rats. Methods: a total of fifteen male Holtzman albino rats were randomly assigned to a Control group (n = 5, no risperidone) and two treatment groups (n = 5 per group) receiving 0.4 mg·kg-1·day-1 and 4.0 mg·kg-1 ·day-1 risperidone, administered via orogastric gavage for 20 consecutive days. After treatment, brain and liver tissues were collected. The activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PDH), and glutathione S-transferase (GST) was analyzed. Reduced glutathione (GSH) levels and lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS), were quantified. Results: findings indicate that in brain tissue, both doses significantly increased CAT activity and decreased the SOD/CAT ratio, and that the high dose significantly reduced TBARS levels. In liver tissue, a significant increase in CAT activity was observed with the high dose. Furthermore, both doses significantly increased G6PDH activity and reduced TBARS levels. Conclusions: these results underscore the influence of risperidone on cerebral and hepatic oxidative metabolism during the subacute phase. Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0. https://creativecommons.org/licenses/by/4.0/

Instituciones: Universidad Nacional Mayor de San Marcos