Emergence of Macrolide-Resistant Bordetella pertussis, Peru, 2025

Juscamayta-López E.; Valdivia F.; Rodríguez-Cueva C.; Horna H.; Quispe Y.; Soto M.P.; Torres S.; Fiestas Solórzano V.; Yagui M.; Vicente Cantarelli V.; Montilla-Escudero E.; Silva V.; Da Costa A.R. · Emerging Infectious Diseases (2026) · DOI: 10.3201/eid3210.251477

Resumen

We report the emergence of macrolide-resistant Bordetella pertussis during a pertussis outbreak in Peru. Among 68 cases, 31% carried the A2047G gene mutation, conferring resistance to macrolides. Whole-genome sequencing revealed 2 genetically distinct groups, indicating multiple introductions into Peru. Our findings support strengthening surveillance for macrolide-resistant pertussis to inform control strategies.