Effects of glucagon-like peptide-1 receptor antagonist in the treatment of patients with obesity and Type 2 diabetes mellitus

Mejía-Zambrano H. · Revista Habanera de Ciencias Medicas (2022)

Resumen

Introduction: New drugs with novel mechanisms of action and fewer adverse effects have recently been discovered for the treatment of type 2 diabetes. Among them are glucagon-like peptide-1 analogues. Objective: To explain the existing evidence of the effects of treatment with glucagon-like peptide-1 receptor agonists in people with obesity and type 2 diabetes mellitus. Material and Methods: We conducted a systematic review that included studies on the effects of glucagon-like peptide-1 receptor agonists for the treatment of people older than 12 years with obesity and type 2 diabetes. A formal narrative synthesis of the collected data was performed, whereas a formal statistical synthesis was not performed. The quality of evidence for each outcome was determined according to the Grading of Recommendations Assessment, Development and Evaluation method. Results: The available evidence shows that glucagon-like peptide-1 receptor agonists achieved a greater reduction in body weight (-7,0 % vs -2 %) and glycosylated hemoglobin (HbA1c) (-0,40 % vs -0,10 %) compared to the placebo group. In addition, there was a greater reduction in abdominal waist circumference. Conclusions: The evidence analyzed shows that glucagon-like peptide-1 receptor agonists have beneficial effects in the treatment of people with obesity and diabetes, reducing body weight and glycemia values.

Instituciones: Universidad Privada San Juan Bautista