Effectiveness of COVID-19 vaccination in vaccinated versus unvaccinated cancer patients

Gamarra R.R.M.; Machicao A.I.S.; Andrade Ó.E.G.; Cuellar J.F.S.; Linares R.L. · Revista Venezolana de Oncologia (2024)

Resumen

OBJECTIVE: The vaccination in the cancer patients is not as effective compared to the healthy people. Our objective was to investigate the effectiveness of 5 types of COVID-19 vaccines in the cancer patients to prevent severe disease and the death. METHOD: Retrospective case control study in 968 cancer patients, divided into the vaccinated groups: 462 cases and the unvaccinated groups: 506 cases, developed at the Carlos Seguin Escobedo National Hospital, in Peru. To compare the groups, Pearson’s χ2 test or the Fisher’s exact test was used. The OR was evaluated retrospectively for 40 months. To evaluate the effectiveness of the vaccine types, Kruskal-Wallis rank sum was tested. RESULTS: The vaccinated patients when infected with SARS-CoV-2 had mild disease in the majority (83.8 %), compared to the unvaccinated patients, which was only mild in 26 %. For patients over 60 years of age, the vaccination showed effectiveness of 91 %. When 4 doses were completed, the was effectiveness in 98.42 % to prevent severe disease and 96.79 % to avoid severe disease and death. CONCLUSION: The vaccines are effectiveness in preventing serious illness or death, with no statistical difference between the 5 types of vaccines, evaluated in an exclusively oncological population.

Instituciones: Universidad Católica de Santa María