Effect of treatment with Mangifera indica L. peel powder on markers of liver damage in ethanol-intoxicated mice

Paredes Contreras J.H.; Roldan Cuba A.V.; Palomino Arias A.G.; Puelles-Samaniego O.I.; Molano Landeo C.A.; Goicochea Flores S.; Huamán-Gutierrez O.G. · Nutricion Clinica y Dietetica Hospitalaria (2025) · DOI: 10.12873/454paredes

Resumen

Introduction: Liver diseases are one of the most important causes of morbidity and mortality in Peru and worldwide, with chronic alcohol consumption being one of the main risk factors for the development of these pathologies. Objective: To determine the effect of Mangifera indica H. (mango) peel powder on ethanol-induced liver toxicity in mice. Materials and methods: A purely experimental approach was used with a post-test and a control group. Thirty-five male albino Mus musculus BALB/c mice, three months old, were treated with Mangifera indica H. peel powder. The mice were randomly assigned to groups. To induce liver damage, 5% ethanol in 5% glucose solution was administered orally in groups II to V for five days. In the afternoon, a 1% starch suspension was administered to the aforementioned groups. Silymarin (70 mg/kg), mango peel (100 mg/kg), and mango peel (900 mg/kg) were used as transport media for groups III, IV, and V, respectively. The mice were fasted for 12 hours before undergoing open incisional laparotomy for liver removal and analysis. Results: Groups IV and V were significantly lower in liver function compared to group II. Also, lower levels of lipid peroxidation (p < 0.05) and SOD/CAT ratio (p < 0.15) were observed, with an increased GSH profile, confirming the findings of the histological analysis. Conclusions: Ingestion of Mangifera indica (mango) peel had a hepatoprotective effect against ethanol toxicity in mice.

Instituciones: Universidad Peruana Cayetano Heredia; Universidad Nacional Mayor de San Marcos