Effect of Corryocactus brevistylus fruit juice on rats with paracetamol poisoning

Huamán Gutiérrez O.G.; Soberón Lozano M.M.; Huamán Gutiérrez J.M. · Nutricion Clinica y Dietetica Hospitalaria (2025) · DOI: 10.12873/454huaman

Resumen

Introduction: Liver diseases progress silently but disrupt nutrient metabolism, leading to a decline in nutritional status. Sanky is a high-Andean fruit from the Peruvian region that contains bioactive substances such as polyphenols (flavonoids), vitamins, carotenoids, and other compounds. Objective: To evaluate the effect of Corryocactus brevistylus (sanky) fruit juice on the liver tissue of rats intoxicated by paracetamol. Materials and methods: An experimental design was used. Sanky fruit juice was used, and 48 Rattus norvegicus Holtzman rats (240-270 g) were randomly assigned to six groups (n=8). Treatments were administered orally for 10 days: groups I and II received 0.9% NaCl, group III received 100 mg/kg of silymarin, and groups IV, V, and VI received 1, 5, and 10 mL/kg of juice, respectively. From the sixth day onward, paracetamol (400 mg/kg) was administered to groups II-VI. After treatment, blood and liver samples were obtained for biochemical (AST, ALT, GGT, ALP, total and direct bilirubin, total protein, albumin, and lipid peroxidation) and histological analysis. The results were analyzed using one-way ANOVA with Tukey’s post-hoc test (p < 0.05). Results: Administration of the juice at different doses resulted in lower AST, ALT, GGT, and direct and total bilirubin activity, and higher concentrations of total protein and serum albumin, showing a significant difference compared to group II. However, it showed an increase in alkaline phosphatase activity and lipid peroxidation (liver and serum). The liver index was lower, and histologically, there was better preservation of structures. Conclusion: Sanky fruit juice exhibits a hepatoprotective effect in rats with paracetamol-induced liver toxicity, as evidenced by biochemical markers in liver tissue and serum.

Instituciones: Universidad Nacional Mayor de San Marcos