Effect of Chenopodium ambrosioides (paico) spray on liver biochemical markers in rats versus ethanol and fructose consumption

Puelles-Samaniego O.I.; Huamán-Gutierrez O.G.; Turriate Aguilar P.S.; Gonza Tito P.A.; Vega Salazar P.C.; Paredes Contreras J.H. · Nutricion Clinica y Dietetica Hospitalaria (2025) · DOI: 10.12873/454puelles

Resumen

Introduction: Chronic liver diseases, such as alcoholic and non-alcoholic fatty liver disease, represent a significant public health challenge worldwide. The proper identification and management of risk factors such as obesity, diabetes, and dyslipidemia are essential for the prevention and control of these diseases. Objective: To evaluate the effect of Chenopodium ambrosioides (paico) spray on liver biochemical markers compared to ethanol and fructose consumption in rats. Materials and methods: Experimental design. Twenty-five male rats were used. To induce hepatotoxicity, which lasted 22 days, groups II-V received a 5% ethanol/15% fructose mixture in their water bowls, while group I received only water. From the balanced diet, paico powder was added 1% (group III), 3% (group IV) and 9% (group V), while groups I-II received only a balanced diet, said treatment lasted 22 days. After treatment and after 10 hours of fasting, the animals were anesthetized with sodium pentobarbital. Subsequently, the liver was extracted, which was sectioned into three portions for histological analysis, and two for the preparation of homogenate where molecular markers were determined. Results: Chenopodium ambrosioides (paico) powder demonstrated a potent hepatoprotective effect, reversing induced steatosis with a 33.3% reduction in hepatic triglycerides, also achieving the restoration of synthetic function (Prot. α) and a greater increase in redox balance (GSH/GSSG). Conclusions: The consumption of Chenopodium ambrosioides (paico) powder has a hepatoprotective effect.

Instituciones: Universidad Nacional Mayor de San Marcos