Effect of Chenopodium ambrosioides (paico) powder on lipid metabolism markers in rat liver, compared to ethanol and fructose consumption

Puelles Samaniego O.I.; Huamán Gutierrez O.G.; Turriate Aguilar P.S. · Nutricion Clinica y Dietetica Hospitalaria (2024) · DOI: 10.12873/444puelles

Resumen

Introduction: Chronic liver diseases (CLD) have a high morbidity and mortality rate worldwide, with an alarming increasing trend; liver cirrhosis being the final stage and the most frequent chronic expression of liver disease. Objective: To evaluate the effect of Chenopodium ambrosioides (paico) spray versus ethanol and fructose consumption in rat liver. Materials and methods: Experimental design. Twenty-five male rats were used. Group I was provided with balanced food and water, this being our control group. For the induction of hepatotoxicity, which lasted 22 days, a mixture of 5% ethanol/15% fructose was administered in their drinkers to groups II-V. Paico spray was added to the balanced diet at 1% (group III), 3% (group IV) and 9% (group V), while groups I-II received a balanced diet. After treatment and 10 hours of fasting, the animals were anesthetized with sodium pentobarbital, and the liver was then removed. Three portions were sectioned for histological analysis and two for homogenate preparation, where molecular markers were determined. Results: Consumption of 3% paico increased PPAR-α levels, while PPAR-γ increased in groups III, IV, and V. SREBP was more inhibited at 3% paico. The PPAR-α/SREBP and Ppar-γ/SREBP ratios increased in relation to the percentage of paico. Conclusions: Consumption of Chenopodium ambrosioides (paico) powder has a hepatoprotective effect at a medium dose for the model studied.

Instituciones: Universidad Nacional Mayor de San Marcos