Economic burden of Chagas disease in Latin American countries: a population-based cost-of-illness analysis from the RAISE study

Andrade M.V.; Noronha K.V.M.D.S.; de Souza A.; Julião N.A.; Motta-Santos A.S.; Franco Braga P.E.; Bracarense H.; Alves do Santos A.B.; Nascimento B.R.; Eloah Machado Í.; Martins-Melo F.R.; Molina I.; Perel P.; Geissbühler Y.; Demacq C.; Castro Jaramillo H.E.; Echeverría L.E.; Principato M.B.; Aguilera Mora L.F.; Fernandez M.L.; Nina Calisaya J.J.; Pinho Ribeiro A.L. · The Lancet Regional Health - Americas (2026) · DOI: 10.1016/j.lana.2025.101340

Resumen

SummaryBackgroundChagas disease (ChD) remains a public health concern in Latin America. Despite a decline in overall prevalence, the chronic symptomatic forms still impose a substantial epidemiological and economic burden. This study undertakes a comprehensive, population-based cost analysis of chronic Chagas disease (CCD) from a societal perspective in seven endemic Latin American countries for 2010 and 2023.MethodsA Markov model with one-year cycles and six states was employed. Direct medical and indirect costs, converted to 2024 purchasing power parity US dollars, were estimated using prevalence data from the Global Burden of Disease Study 2023. Based on a previous Brazilian Markov model, parameters were adjusted using healthcare coverage and per capita health expenditure ratios for each country, further validated by national experts.FindingsIn 2010, Brazil (US$252 billion) and Argentina (US$164 billion) had the highest lifetime burdens. As a percentage of annual Gross Domestic Product, Bolivia (0·9%) and Argentina (0·8%) were most affected. CCD accounted for 6% of total health expenditures in both countries. Between 2010 and 2023, most countries experienced a decline in economic burden due to decreased CCD prevalence, despite an increased proportion of patients with cardiac conditions, reflecting population aging and disease progression.InterpretationCCD imposes substantial economic burden across Latin American countries. Epidemiological shift to older populations with severe cardiac forms signals increased healthcare demands. Findings inform policymakers for resource allocation and tailored interventions.FundingFunding was provided by Novartis Pharma AG as part of a research collaboration with the World Heart Federation (project number CLCZ696D2010R).