Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child

Montalvo R.; Díaz A.; Montalvo J.; Pomazongo M.; Montalvo M.; Tunque E. · IDCases (2022) · DOI: 10.1016/j.idcr.2022.e01507

Resumen

The association of paracoccidioidomycosis (PCM) and tuberculosis (TB) produces an uncommon hyperinflammatory syndrome, causing multiorgan dysfunction. TB associated PCM is a rare condition, but it is fatal if not treated. Herein, we present a immunocompetent child who is admitted for fever and painful lymphadenopathy, with evidence of acid-alcohol-resistant bacillus (AARB) in cervical lymph node biopsy, antituberculous treatment was started with partial clinical improvement and is given discharge from hospital. At 3 weeks, he was readmitted by fever, weight loss, dyspnea and a greater number of adenopathies, in the new biopsy multiple yeasts were found compatible with PCM, our patient responded well to the combination of antituberculosis therapy(ATT), corticosteroid, and amphotericin B deoxycholate, presenting clinical improvement and subsequently continued with itraconazole.

Instituciones: Universidad Nacional Daniel Alcides Carrión; Universidad Continental; Universidad de Huánuco; Universidad César Vallejo