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Dimethyl sulfoxide pretreatment enhances long-term bonding of universal adhesives to endodontically modified dentin

Zaniboni J.F.; Besegato J.F.; Verbicário dos Santos J.R.E.; Gelio M.B.; Escalante-Otárola W.G.; Kuga M.C. · International Journal of Adhesion and Adhesives (2026) · DOI: 10.1016/j.ijadhadh.2026.104316

Resumen

Purpose: This study evaluated the effect of dimethyl sulfoxide (DMSO) pretreatment on the microtensile bond strength (μTBS) and adhesive interface characteristics of universal adhesives systems applied in etch-and-rinse mode to endodontically modified dentin irrigated with calcium hypochlorite. Materials and methods: For μTBS analysis, 240 bovine dentin specimens were divided into eight experimental groups according to the adhesive system used, DMSO pretreatment or not, and the evaluation period (24 h, 6 months, and 12 months) (n = 10). Failure modes and adhesive interface characteristics were also analyzed. μTBS data were analyzed using two-way ANOVA and Tukey tests, and adhesive interface scores were analyzed using Kruskal-Wallis and Dunn tests (α = 0.05). Results: DMSO pretreatment resulted in significantly higher bond strength after 12 months compared with non-treated groups, while no significant differences were observed among evaluation periods for DMSO-treated specimens. In contrast, specimens bonded without DMSO exhibited a significant reduction in bond strength after aging. Failure mode analysis revealed a higher incidence of cohesive failures in DMSO-pretreated groups, particularly after long-term storage. Adhesive interface analysis showed increased resin tag formation and greater interfacial continuity in DMSO-treated dentin. Conclusion: These findings indicate that DMSO pretreatment improves the long-term stability of resin–dentin bonds and promotes more favorable interfacial characteristics in dentin previously exposed to calcium hypochlorite. DMSO may therefore represent a promising strategy to enhance bonding durability in endodontically modified dentin.

Instituciones: Universidad Católica de Santa María