Diagnostic validity of a mechanical ventilation weaning protocol

Fernandez Merjildo D.; Porras García W. · Revista Medica Herediana (2026) · DOI: 10.20453/rmh.v37i2.6830

Resumen

Objective: To determine the diagnostic validity of a protocol for predicting successful weaning from mechanical ventilation (MV). Methods: An observational study of instrument validation was conducted in a cohort of 92 patients receiving MV for more than 24 hours. The protocol consisted of 15 criteria: resolution of the cause leading to MV, positive end-expiratory pressure (PEEP) ≤ 8 cm of water, PaO2/FiO2 ≥150 mm Hg, FiO2 ≤ 40%, hemodynamic stability, normal serum potassium and phosphorus levels, successful spontaneous breathing trial, negative cuff leak test, adequate level of consciousness, effective cough and swallowing, minimal tracheal secretions, and the use of noninvasive ventilation (NIV) or high-flow nasal cannula (HFNC) after extubation. Results: The protocol showed a sensitivity of 10.8%, specificity of 100%, positive predictive value of 100%, negative predictive value of 10.8%, and an area under the ROC curve of 0.86. Conclusion: The protocol demonstrated low sensitivity and high specificity for predicting successful weaning; therefore, it was more useful for confirming weaning success than for identifying all patients potentially suitable for weaning. © Los autores. Artículo de acceso abierto, distribuido bajo los términos de la Licencia Creative Commons Atribución 4.0 Internacional.

Instituciones: Universidad Peruana Cayetano Heredia