Diagnostic accuracy of Triglyceride-Glucose Index for diagnosis of metabolic syndrome in a primary care facility of the San Martin region, Peru. A cross-sectional study

Alburqueque-Melgarejo J.; Roque-Quezada J.C.; Flores H.M.V.; Cuyutupac I.A.G.; Valencia J.G.; del Rosario Quezada Gómez G. · Revista Espanola de Nutricion Humana y Dietetica (2024) · DOI: 10.14306/renhyd.28.4.2185

Resumen

Introduction: In recent years, multiple studies throughout the world have shown that the Triglyceride Glucose Index has adequate diagnostic performance in patients with metabolic syndrome. The objective of the present study was to determine the usefulness of the Triglyceride Glucose Index for the diagnosis of Metabolic Syndrome in patients treated in a primary care facility in the Peruvian jungle during the period 2022-2023. Methodology: Diagnostic Accuracy Study with a Cross-Sectional Design. A documentary analysis of medical records from 363 patients was conducted. The outcome was the presence of metabolic syndrome (MS), defined according to ATP-III criteria. The TyG index was the evaluated test, calculated using the formula: Ln [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were analyzed, along with their respective 95% confidence intervals (95%CI) and optimal cutoff points determined using Youden’s index, both for the total sample and stratified by sex. Results: A cut-off point of 8.97 was obtained for ITG values with a sensitivity of 89.5% and a specificity of 64.3% for the diagnosis of metabolic syndrome. The area under the curve (AUC) for ITG was 0.889 (95%CI: 0.851-0.922, p<0.005). Additionally, the positive predictive values (82.49%), negative (76.42%) and diagnostic accuracy (80.72%) were calculated. Based on the local prevalence of metabolic syndrome in the studied population, the Fagan normogram was prepared and the positive (2.505) and negative (0.1641) likelihood ratios were obtained, from which the post-test probability was calculated. when the test was positive (82%; 95%CI: 79-86%) and when the test was negative (23%; 95%CI: 17-31%). Conclusions: The present study indicates that the Triglyceride Glucose Index is a reliable diagnostic tool to evaluate the presence of metabolic syndrome in high-risk individuals.

Instituciones: Universidad Privada San Juan Bautista; Universidad César Vallejo; Universidad Privada del Norte