Diagnostic Accuracy of Insulin Resistance in Diabetes and Prediabetes

Zuzunaga-Montoya F.E.; Vásquez-Romero L.E.M.; Loayza-Castro J.A.; Carrillo C.I.G.D.; Vigil-Ventura E.; Vera-Ponce V.J. · Revista Cubana de Medicina Militar (2025)

Resumen

Introduction: It has been suggested that the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) could serve as an additional test to support and complement existing tests for hyperglycemic states. Objective: To determine the diagnostic capacity of HOMA-IR for Type 2 diabetes mellitus (T2DM) and prediabetes. Methods: Diagnostic test study. Both were measured according to elevated fasting; postprandial, and glycosylated hemoglobin levels. The receiver operating characteristic curve (ROC) along with its corresponding area under the curve (AUC) was used to evaluate diagnostic efficacy. Sensitivity and specificity metric were calculated. Results: The prevalence of prediabetes and T2DM were 18.82% and 10.52%, respectively. The median HOMA-IR was 1.33. HOMA-IR had an AUC of 0.843 for prediabetes in the total population, with a

Instituciones: Universidad Tecnológica del Perú; Universidad Continental; Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas