Determination of the standardized uptake value (SUV) of 18F-FDG in PET/CT in the simulation of lesions less than or equal to 10 millimeters in air and lung mannequin

Sequeiros-Palomino I.; Neyra-Aguilar F.A.; Meza-Salas W.J.; Correa-Ñaña R.E. · Revista Medica Herediana (2025) · DOI: 10.20453/rmh.v36i3.7044

Resumen

Positron emission tomography (PET) images contribute to the metabolicevaluation of lesions at all stages using the radiopharmaceutical 18F-FDG (Fluorine-18-fluorodeoxyglucose); oncology is its main indication. The most used parameteris the standardized uptake value (SUV). Studies suggest further research into themetabolic quantification of lesions ? 10 mm in PET. Objective: To determine theaccuracy of SUV in the simulation of lesions ? 10 mm in air and lung mannequinwith point radioactive sources of 18F-FDG. Methods: Experimental study basedon 36 simulations in air and 36 simulations in a lung mannequin. Measures ofcentral tendency were described, and the medians of SUVPET and SUVtheoretical inair and lung mannequin were compared using the non-parametric Wilcoxon-Mann-Whitney test. Results: SUV accuracy in simulations of lesions ?10 mmshowed systematic overestimation, greather in air than in the lung mannequin, exceeding the 5% uncertainty recommended by the International Atomic EnergyAgency (IAEA). Conclusions: The accuracy percentage of SUVPETmax, SUVPETmedand SUVPETmin values presented a value greather than 5%; the estimates showedsignificant deviation for this size range, making SUV quantification difficult forlesions smaller than 10mm. © Los autores.

Instituciones: Universidad Peruana Cayetano Heredia; Universidad Nacional Federico Villarreal