Destructive cervicofacial actinomycosis: a fatal case report and literature review

Vargas Machuca-Carranza C.A.; Rodríguez-Chávez L.Á.; Sáenz - Lázaro J.M.; San Martín-Loyaga M.L.E. · Medicina Clinica Practica (2026) · DOI: 10.1016/j.mcpsp.2026.100543

Resumen

Cervicofacial actinomycosis is a rare chronic bacterial infection caused by Actinomyces spp., anaerobic microorganisms that are part of the normal oral flora. Its clinical presentation may mimic neoplastic or granulomatous diseases, leading to diagnostic delays. We report the case of a 65-year-old man with a history of dental extraction who developed a progressive and destructive ulcerative lesion in the right nasogenian region, unresponsive to empirical antibiotic therapy. The diagnosis was confirmed by histopathological examination. Despite the use of broad-spectrum antibiotics and intensive care management, the patient showed unfavorable clinical evolution and died due to septic shock. This case highlights the potential aggressiveness of cervicofacial actinomycosis and underscores the importance of early diagnosis and prompt targeted treatment.

Instituciones: Universidad Privada Antenor Orrego