Design and development of a modular perfusion bioreactor prototype using 3D printing

Cabrera R.A.G.; Núñez M.A.R.; Salas R.M.S.; MacEdo E.A.; Martinez-Flores J.E.; Torres-Ayala L.K.; Vela P.; Castillo D. · Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (2024) · DOI: 10.1109/embc53108.2024.10782877

Resumen

This study outlines the conceptual and design framework for a modular bioreactor intended to advance accessibility in tissue engineering by providing an optimal environment for three-dimensional cell growth and differentiation. By integrating 3D printing technology, we propose an innovative and cost-effective approach to bioreactor fabrication streamline the development and customization of tissue engineering applications. While the actual cell cultivation within the bioreactor has yet to be undertaken, preliminary analyses - including rigorous rheological evaluation and computational simulations - validate the bioreactor's potential to maintain a uniform, contamination-free culture environment. This research sets the stage for future experimental work, aiming to validate the bioreactor's effectiveness in supporting cell development and specialization. The anticipated outcomes promise to mark a significant step toward the clinical translation of bone tissue engineering solutions, embodying a new horizon in regenerative medicine.

Instituciones: Universidad Peruana Cayetano Heredia; Pontificia Universidad Católica del Perú