Description of a case of Rosai-Dorfman disease involving the breast and literature review

Yan-Quiroz E.F.; Loayza-Silva C.C.; Tenazoa-Villalobos J.R. · Revista de Senologia y Patologia Mamaria (2026) · DOI: 10.1016/j.senol.2026.100758

Resumen

Rosai-Dorfman disease, also referred to as sinus histiocytosis, is a benign proliferative disorder of Langerhans cells that predominantly affects individuals in their twenties. The aetiology is associated with immunological alterations or pathogen-mediated responses. Definitive diagnosis is established through excisional biopsy and histopathological examination. The disease is defined by proliferative histiocytes exhibiting emperipolesis, characterised by the engulfment of one inflammatory cell by another. These histiocytes demonstrate positivity for S100 and CD68 markers. Management strategies include observation, follow-up, corticosteroid therapy, surgical intervention, and, in selected cases, chemoradiotherapy. This report describes a 39-year-old woman with Rosai-Dorfman disease of the right breast who did not respond to corticosteroid therapy and subsequently underwent surgical intervention, resulting in a favourable outcome without recurrence . Copyright

Instituciones: Universidad Privada Antenor Orrego