Description of a case of apocrine encapsulated papillary carcinoma of the breast: A diagnostic dilemma

Tenazoa-Villalobos J.R.; Yan-Quiroz E.F.; Llerena-Cobián G. · Revista de Senologia y Patologia Mamaria (2025) · DOI: 10.1016/j.senol.2024.100653

Resumen

Encapsulated papillary carcinoma of the breast with apocrine differentiation is an extremely rare neoplasm that possesses both an encapsulated papillary configuration as well as epithelial cells that differentiated apocrine. It is not included as such in the fifth edition of the World Health Organization (WHO) classification of tumors because there are no research studies on the subject. These neoplasms have cells that are distinguished by having granular cytoplasm, large nuclei with prominent nucleoli, through immunohistochemistry these tumors are negative for estrogen, progesterone and HER2 receptors, but despite the absence of these markers and the nuclear atypia described, they have an overall survival that exceeds 5 years compared even to the other types of triple-negative breast neoplasm. We present the case of an 85-year-old woman who presented a right breast tumor that was classified as apocrine encapsulated papillary carcinoma, underwent right total mastectomy surgery and allowed the control of the disease, thus achieving a favorable outcome.

Instituciones: Universidad Privada Antenor Orrego; Universidad César Vallejo