Cross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin America

Nieto R.E.; Hernández L.; Quintana R.; Fernández-Ávila D.; Santillan E.P.; Subils G.; Otaduy C.; Saurit V.; Arturi V.; Sattler M.E.; Lucero L.G.; Grageda W.P.; Pérez N.; Cosatti M.; Crespo Espindola M.E.; Serventi J.M.; Oliveira e Silva Montandon A.C.D.; Gasparin A.A.; Duarte A.; Alvino L.; Borba E.F.; Parente L.; Reis Neto E.T.D.; Herrera I.G.; Massardo L.; Martínez G.A.; Medina H.; Cañas Davila C.A.; Quintana-Lopez G.; Toro-Gutiérrez C.E.; Martínez J.; Sánchez Briones R.E.; Cristóbal M.P.; Martin-Nares E.; Juárez-Vicuña Y.; De La Torre I.G.; Mendoza C.A.; Esquivel-Valerio J.A.; Langjahr P.; Vazquez M.A.; Cieza Calderón J.N.; Ugarte-Gil M.F.; Quiroz A.C.; Álvarez R.; Pizzarossa C.; Danza Á.; Gómez-Puerta J.A.; Pons-Estel B.A.; Pons Estel G.J.; Peláez-Ballestas I. · International Journal of Rheumatic Diseases (2026) · DOI: 10.1111/1756-185x.70641

Resumen

Objective: The objective of this study is to perform a cross-cultural validation of the Work Productivity and Activity Impairment (WPAI-Lupus v2.0) questionnaire in Latin American individuals with systemic lupus erythematosus (SLE), using data from the GLADEL cohort. Methods: GLADEL 2.0 is an observational cohort of SLE patients ≥ 18 years old. Clinical data, disease activity (SLEDAI-2 K), damage index (SDI), physician's global assessment (PGA) and patient-reported outcomes (WPAI-Lupus v2.0, LupusQoL), were assessed at baseline and during follow-up. Construct validity was evaluated through Spearman correlations with SLEDAI-2 K, SDI and LupusQoL. Internal consistency was assessed using Cronbach's alpha and responsiveness over 12 months was analyzed using the Wilcoxon signed-rank test. Appropriate statistical tests (p < 0.05) were performed using R software, version 4.4.0. Results: Among 1083 patients, 684 were evaluated at baseline and at 12 months. Cronbach's alpha values were: absenteeism 0.54; presenteeism 0.64; overall work impairment 0.62; activity impairment 0.62. WPAI-Lupus v2.0 scores correlated with SLEDAI-2 K (p < 0.001) and negatively with LupusQoL domains. Moderate correlations were observed between activity impairment and physical health, pain and planning (r ≈ −0.52 to −0.58). Presenteeism and overall work impairment also showed moderate correlations with physical health and pain domains (r ≈ −0.49 to −0.53). WPAI-Lupus v2.0 was sensitive to change over 12 months (p = 0.001) for all domains except intimate relationship. Conclusions: WPAI-Lupus v2.0 demonstrated good validity, internal consistency, and responsiveness. It correlated with disease activity and quality of life, supporting the WPAI-Lupus v2.0 as a valid tool to assess work and activity impairment in Latin American patients with SLE.

Instituciones: Universidad Peruana Cayetano Heredia; Universidad Científica del Sur