Cordiosides A and B, two new 19-hydroxy-29-norlanostane glycosides isolated from the flowers of Cordia lutea

Castro Dionicio I.Y.; Fabre N.; Saffon-Merceron N.; Sauvain M.; Castillo D.; Jullian V. · Phytochemistry Letters (2022) · DOI: 10.1016/j.phytol.2022.08.015

Resumen

We present here the isolation and structural characterization of two undescribed mono-glycosylated triterpenes with a 19-hydroxy-29-norlanostane core. These compounds (1-2) were isolated from an ethanolic extract of the dried flowers of Cordia lutea, a widely used Peruvian traditional medicine. Their structures were determined by examination of their NMR and MS data. For compound 1, its structure was confirmed by single crystal X-ray structural analyses. 1 showed moderate activity against Helicobacter pylori (MIC = 15.6 µg/mL), and was not active against Escherichia coli, Pseudomonas aeruginosa or Staphylococcus aureus (MIC > 125 µg/mL).

Instituciones: Universidad Peruana Cayetano Heredia