Conservative management with radiotherapy and immunochemotherapy in primary diffuse large B-cell lymphoma of the cervix: Diagnosis and treatment of a rare entity

Robles Díaz J.F. · Clinica e Investigacion en Ginecologia y Obstetricia (2023) · DOI: 10.1016/j.gine.2023.100857

Resumen

Introduction: Primary malignant cervical lymphoma is a very rare disease, which represents only 0.008% of all cervical tumors and 2% of all female extranodal lymphomas. Main symptoms and/or clinical findings: The case of a 66-year-old woman from the Peruvian Andes is presented, with a disease period of 4 months characterized by gynaecorrhagia, with evidence of a 5 cm tumor cervix. Immunohistochemistry was performed on the biopsy of cervix to differentiate lymphoma from squamous cell carcinoma. Primary diagnosis: Primary diffuse large B-cell lymphoma of the cervix with Ann Arbor IE IPI low-risk staging. Therapeutic interventions and results: She being managed with immunochemotherapy (rituximab, cyclophosphamide, adriamycin, vincristine and prednisone), followed by consolidative external radiotherapy at a dose of 3,000 cGy in 15 sessions with a special IMRT technique. Resulting in satisfactory disease control and no complications from irradiation. Conclusion: Primary diffuse large B-cell lymphoma of the cervix is very rare, therefore, in a case of primary stromal lesion of the cervix, suspicion of lymphoma should be taken into account.

Instituciones: Universidad Peruana Los Andes