CONGENITAL TOXOPLASMOSIS WITH SEVERE NEUROLOGICAL DISEASE IN A REFERRAL HOSPITAL IN PERU

Maquera-Afaray J.; Luna-Vilchez M.; Salazar-Mesones B.; Chiara-Chilet C.; Cordero-Campos A.; López J.W. · Revista Peruana de Medicina Experimental y Salud Publica (2022) · DOI: 10.17843/rpmesp.2022.392.10897

Resumen

The aim of this study was to describe the epidemiological, clinical, and therapeutic characteristics of patients diagnosed with congenital toxoplasmosis (CT) with severe neurological disease. We reviewed the medical records of patients under 1 year of age with positive IgM test for Toxoplasma gondii and brain, eye, and/or hearing involvement. This study was carried out at the Instituto Nacional de Salud del Niño San Borja (INSNSB), Lima, Peru. Twenty-one patients diagnosed with CT were evaluated; 57.1% were female, and the median age at diagnosis was 3.1 months (IQR: 1.7-7.3). The main central nervous system manifestations were hydrocephalus (76.2%), intracranial calcifications (52.4%), microcephaly (42.9%), and convulsions (25.6%); the most frequent ocular manifestation was chorioretinitis (38.1%). In conclusion, 64% of CT cases had one or more manifestations of severe neurological disease.

Instituciones: Universidad Peruana Cayetano Heredia; Universidad Científica del Sur; Universidad Privada de Tacna