Competitive Host-guest Electrochemical Detection of Ivermectin Drug Using a β-Cyclodextrin/Graphene-based Electrode

Silva M.K.L.; Simões R.P.; Leão A.L.; Lapa R.M.L.; Rascón J.; Cesarino I. · Electroanalysis (2023) · DOI: 10.1002/elan.202100649

Resumen

The present study describes the novel development and application of an ivermectin (IVM) sensing electrochemical platform based on reduced graphene oxide (rGO) and the macrocyclic host β-cyclodextrin (β-CD) molecule. The sensing method was based in the host-guest characteristics of β-CD and competitive interaction between the target analyte and the methylene blue (MB) redox probe. Differential pulse voltammetry (DPV) was employed for the detection of IVM and a linear response between 0.5 and 40.0 μmol L−1 with a limit of detection of 0.25 μmol L−1 was obtained using the glassy carbon (GC)/rGO/β-CD electrode. The sensing platform was successfully applied for the detection of IVM in tap water samples, which may expand the applications of β-CD towards the analysis of other chemical species.

Instituciones: Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas