CLINICOPATHOLOGICAL CHARACTERISTICS AND DISEASE-FREE SURVIVAL OF PEDIATRIC PATIENTS WITH WILMS TUMOR

Paz Soldan Mesta C.F.; Gonzales Fernandez L.H.; Paz Soldan Oblitas C.E. · Revista de la Facultad de Medicina Humana (2026) · DOI: 10.25176/rfmh.v26i1.7329

Resumen

The aim of this study was to describe the epidemiological, clinical, surgical, and histopathological characteristics, and to evaluate disease-free survival and recurrence. A retrospective observational cohort study was conducted on 45 patients under 15 years of age with a histopathologically confirmed diagnosis of Wilms tumor, who were treated between 2000 and 2020. Medical, surgical, and pathology records were reviewed. Males predominated (53.3%), the mean age was 3.6 years, and Stage II was the most common (40.0%). Additionally, 53.3% received neoadjuvant chemotherapy and 46.7% underwent primary surgery. Open radical nephrectomy was performed in 95.6% of cases, margins were negative in 84.4%, and mixed histology was the most common (53.3%). Nine patients experienced recurrence, six died, and five discontinued treatment. Disease-free survival was 82.3% at two years. Article published by the Revista de la Facultad de Medicina Humana of Universidad Ricardo Palma. It is an open access article, distributed under the terms of the Creative Commons License: Creative Commons Attribution 4.0 International, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/non-commercial use, distribution and reproduction in any medium, provided that the original work is duly cited.

Instituciones: Universidad Nacional Federico Villarreal