Clinical Characteristics, Management, and Prognosis of Newborns with Aplasia Cutis Congenita Type I: A Systematic Review and Case Report

Uribe-Cavero L.J.; Chavez-Ecos F.A.; Chumán-Sánchez M.; Parra-Huaroto A.M.; Neyra-Leon J.; Torres-Huamani D.O.; Siguas-Huasquiche A.; Tarazona-Vilca S.; Bohorquez-Espino E.E.; Anchante-Centeno M.; Alvarado-Gamarra G.; Atamari-Anahui N. · Sage Open Pediatrics (2026) · DOI: 10.1177/30502225261444806

Resumen

Objectives: To synthesize the clinical characteristics, management, and outcomes of newborns with aplasia cutis congenita (ACC) type I. Introduction: ACC type I is a rare congenital condition characterized by isolated scalp defects without associated malformations. Evidence is limited and fragmented. Methods: We conducted a systematic review of studies reporting individual-level clinical data, including case reports, case series, and correspondence describing individual patients, following PRISMA guidelines. An additional clinical case was included. Results: Thirty-six studies, including 69 newborns, were analyzed. Most lesions were solitary (84.1%), located on the vertex (61.9%), superficial (55%), and more frequent in males (60.9%). Management was predominantly surgical. Complications were uncommon (21.3%), and outcomes were generally favorable. Conclusion: ACC type I typically presents as an isolated scalp defect with a favorable prognosis. Lesion characteristics and risk of complications should guide management. © The Author(s) 2026. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Instituciones: Universidad Nacional San Luis Gonzaga; Universidad San Ignacio de Loyola