Circ_0067934 as a novel therapeutic target in cancer: From mechanistic to clinical perspectives

Al-Hawary S.I.S.; Asghar W.; Amin A.; Mustafa Y.F.; Hjazi A.; Almulla A.F.; Ali S.A.-J.; Ali S.S.; Romero-Parra R.M.; Abdulhussien alazbjee A.A.; Mahmoudi R.; Fard S.R.H. · Pathology Research and Practice (2023) · DOI: 10.1016/j.prp.2023.154469

Resumen

Circular RNAs, as a type of non-coding RNAs, are identified in a various cell. Circular RNAs have stable structures, conserved sequence, and tissue and cell-specific level. High throughput technologies have proposed that circular RNAs act via various mechanisms like sponging microRNAs and proteins, regulating transcription factors, and scaffolding mediators. Cancer is one of the major threat for human health. Emerging data have proposed that circular RNAs are dysregulated in cancers as well as are associated with aggressive behaviors of cancer –related behaviors like cell cycle, proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT). Among them, circ_0067934 was shown to act as an oncogene in cancers to enhance migration, invasion, proliferation, cell cycle, EMT, and inhibit cell apoptosis. In addition, these studies have proposed that it could be a promising diagnostic and prognostic biomarker in cancer. This study aimed to review the expression and molecular mechanism of circ_0067934 in modulating the malignant behaviors of cancers as well as to explore its potential as a target in cancer chemotherapy, diagnosis, prognosis and treatment.

Instituciones: Universidad Continental