Chromatographic Methods for the Determination of Rifampicin, Isoniazid, Pyrazinamide, Ethambutol, and Main Metabolites in Biological Samples: A Review

Brozyna-Heredia I.Y.; Ganoza-Yupanqui M.L.; Moreno-Exebio L.; Dos Santos J.L. · Critical Reviews in Analytical Chemistry (2024) · DOI: 10.1080/10408347.2022.2150071

Resumen

Bioanalytical methods are used to quantify drugs and their metabolites in biological samples in order to determine bioequivalence, perform pharmacokinetic and bioavailability studies, and complete therapeutic drug monitoring. The objective of this review paper is to describe bioanalytical methods based on Liquid Chromatography that are used to quantify antitubercular drugs and their metabolites in different biological samples, utilizing scientific literature from 1992 to 2021.

Instituciones: Universidad Nacional de Trujillo