Characterization of isoniazid incorporation into chitosan-poly(aspartic acid) nanoparticles

Zegarra-Urquia C.L.; Santiago J.; Bumgardner J.D.; Goroncy A.K.; Vega-Baudrit J.; Hernández-Escobar C.A.; Zaragoza-Contreras E.A. · International Journal of Polymeric Materials and Polymeric Biomaterials (2024) · DOI: 10.1080/00914037.2022.2145287

Resumen

The incorporation of the drug Isoniazid (an anti-tuberculosis drug) into nanoparticles of polyelectrolyte chitosan-poly(aspartic acid) complexes was carried out by the ionotropic gelation technique, adding a sodium polyaspartate solution containing the drug to a chitosan solution in different proportions in a mass ratio (mg/mg) Isoniazid/Chitosan. This was confirmed by MALDI-TOF/MS, ESI/MS, FTIR, and UV-Vis. The lowest average particle diameter (PD), estimated by DSL, was 148.5 ± 1 nm corresponding to an Isoniazid/chitosan ratio (mg/mg) of 0.5:1. FE-SEM showed nanoparticles in the order of 100–300 nm; whereas AFM showed semi-spherical particle morphology.

Instituciones: Universidad Nacional Mayor de San Marcos