Caregiver willingness to give TPT to children living with drugresistant TB patients

Rouzier V.; Murrill M.; Kim S.; Naini L.; Shenje J.; Mitchell E.; Raesi M.; Lourens M.; Mendoza A.; Conradie F.; Suryavanshi N.; Hughes M.; Shah S.; Churchyard G.; Swindells S.; Hesseling A.; Gupta A. · International Journal of Tuberculosis and Lung Disease (2022) · DOI: 10.5588/ijtld.21.0760

Resumen

BACKGROUND: Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited. METHODS : This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged ,13 years. RESULT S : Of 743 adult and adolescent HHCs, 299 reported caring for children aged ,13 years of age. The median caregiver age was 35 years (IQR 27-48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3-11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2-23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6-12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6-12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1-14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0-112.8). CONCLUS IONS : A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDRTPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.