Ataxia telangiectasia: A review from etiopathogenesis to current management with a description of reported cases in Peru

Araujo-Aliaga I.; Velásquez-Cruz F.; Aguirre-Quispe W.; López-Saavedra A.; Sarapura-Castro E.; Cornejo-Olivas M. · Revista de Neuro-Psiquiatria (2023) · DOI: 10.20453/rnp.v86i1.4463

Resumen

Ataxia-Telangiectasia (AT) is a rare autosomal recessive disease with multisystemic involvement, characterized by slowly progressive ataxia, variable immunodeficiency with recurrent infections, increased risk of neoplasms with or without oculocutaneous telangiectasias. AT is caused by biallelic pathogenic variants within the ATM gene. Its diagnosis is based on suspicion of a compatible clinical symptomatology, increased levels of alpha-fetoprotein, cerebellar atrophy, and genetic testing. There is no curative treatment for AT and its management is based on supportive and preventive measures of eventual complications and genetic counseling. This review updates the epidemiology, clinical manifestations, diagnosis, and treatment of AT, including a search for cases published in Peru.

Instituciones: Universidad Nacional Mayor de San Marcos; Universidad Científica del Sur