Association of sexual orientation outness and recent homophobic violence with not being on antiretroviral treatment: Analysis of a Latin American Survey in men who have sex with men living with HIV

JUAN CARLOS ENCISO DURAND; Alfonso Silva‐Santisteban; Michael Reyes-Diaz; Luis Huicho; Carlos F. Cáceres · Research Square (2026) · DOI: 10.21203/rs.3.rs-9596632/v1

Resumen

Abstract Background In Latin America, up-to-date information to monitor UNAIDS 95-95-95 HIV targets in key populations, such as men who have sex with men, is limited. Elsewhere, structural homophobia restricts access to ART. Conceptual frameworks suggest that intersecting forms of violence and discrimination may negatively influence HIV care outcomes through psychosocial and structural pathways, although empirical evidence remains limited. The study aimed to assess whether sexual orientation outness and recent homophobic violence are associated with not being on ART among Latin American MSM living with HIV. Methods This cross-sectional study is a secondary analysis of data from LAMIS-2018, including 7,609 MSM aged 18 + with an HIV diagnosis ≥ 1 year prior from 18 Latin American countries. Participants self-reported ART status, sociodemographic characteristics, homophobic violence, and sexual orientation outness. Bivariate and multivariate logistic regressions identified those factors associated with not being on ART. Results Nine percent of MSM with HIV were not on ART, 18% reported low sexual orientation outness, and 27% experienced homophobic violence, especially in Andean and Central American countries. Not being on ART was associated with recent homophobic violence (aPR = 1.25), low outness (aPR = 1.22), unemployment (aPR = 1.27), and residence in the Andean subregion (aPR = 1.87), Mexico (aPR = 1.28), or the Southern Cone (aPR = 1.45) versus Brazil. Protective factors included being older (25–39: aPR = 0.72; >39: aPR = 0.49), living in large cities (aPR = 0.72), having a stable partner (aPR = 0.78), and university education (aPR = 0.74). Conclusions Recent homophobic violence and low sexual orientation outness were associated with not being on ART among MSM in Latin America. While access varies across countries, structural factors such as stigma and violence may limit engagement in care. Addressing these barriers alongside strengthening health systems may be key to improving ART uptake and advancing progress toward the 95–95–95 targets.

Instituciones: Universidad Peruana Cayetano Heredia