Association between the levels of gamma-glutamyl transpeptidase and the risk of stroke: systematic review and meta-analysis

Vásquez-Tirado G.A.; Nieto-Rivera S.M.; Quispe-Castañeda C.V.; Meregildo-Rodríguez E.D.; Liñán-Díaz L.J.; Guzmán-Aguilar W.M. · Arquivos de Neuro-Psiquiatria (2025) · DOI: 10.1055/s-0045-1809936

Resumen

Background Stroke is influenced by numerous factors, both modifiable and non-modifiable. Among these, gamma-glutamyl transpeptidase (GGT) serves as a prognostic biomarker in cardiovascular diseases and, within this context, in neurological conditions like stroke. Objective To determine whether an association exists between GGT and both ischemic and hemorrhagic strokes. Methods A systematic and comprehensive literature search was conducted across 5 databases, encompassing studies published from their inception to January 28, 2024, following a population, exposure, comparator, outcome, and study (PECOS) framework. Ten primary studies meeting the eligibility criteria were selected. Results Our findings, based on a meta-analysis of the ten studies, indicate an increased risk of ischemic and hemorrhagic strokes in patients with elevated GGT levels, after excluding outliers. The analysis demonstrated a significant association, with a relative risk of 1.42 (95%CI: 1.01-1.99; I 2 = 19%) for hemorrhagic stroke and 1.22 (95%CI: 1.10-1.36; I 2 = 49%) for ischemic stroke. Conclusion Our study reveals an elevated risk of stroke in patients with high GGT levels, demonstrating a 42% higher likelihood of hemorrhagic stroke and a 22% increased risk of ischemic stroke.

Instituciones: Universidad Privada Antenor Orrego