Association Between Abdominal Obesity and Hyperuricemia in Peruvian Adults with Type 2 Diabetes Mellitus
Peralta-Vera F.G.; Castillo-Céspedes E.; Collazos-Huamán L.D.C.; Guerreros-Espino C.; Herrera-Añazco P.; Benites-Zapata V.A. · Clinical Medicine Insights: Endocrinology and Diabetes (2025) · DOI: 10.1177/11795514251403098
Resumen
Background: Abdominal obesity (AO) is associated with hyperuricemia (HU) in people with type 2 diabetes (T2DM), but most evidence comes from Asian studies and Latin American data are scarce. This study addresses that gap in a Peruvian setting. We aimed to evaluate the association between AO and HU in adult Peruvians diagnosed with T2DM. Methods: We carried out a cross-sectional observational study in adults with T2DM in a private clinic in Lima – Peru. We defined HU as serum uric acid ⩾ 6 mg/dL and defined AO as waist circumference ⩾ 94 cm in men and ⩾88 cm in women. In addition, we estimated crude and adjusted prevalence ratios (PRs) with 95% CIs for the AO–HU association, adjusting for sex, glycosylated hemoglobin, estimated glomerular filtration rate, and systolic/diastolic blood pressure. Results: We evaluated 815 adults with T2DM. 62.6% were male, and the average age was 57 years. AO was present in 82.9% and HU in 22.7%. The prevalence of HU in adults with AO was 24.3%, while the prevalence was 15.1% in those not obese. AO was associated with HU in the crude analysis (cPR: 1.60 95% CI 1.05-2.43) and remained statistically significant after adjustment for sex, glycosylated hemoglobin, estimated glomerular filtration rate, and systolic/diastolic blood pressure (aPR: 1.95 95% CI 1.31-2.90). Conclusion: In Peruvian adults with T2DM, abdominal obesity was associated with nearly double the prevalence of hyperuricemia. Because waist circumference is simple and low-cost to measure, integrating it into routine diabetes visits, along with targeted uric acid screening and management, may enhance cardiometabolic risk stratification and guide timely interventions. © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Instituciones: Universidad Peruana de Ciencias Aplicadas; Universidad Científica del Sur; Universidad San Ignacio de Loyola