Antiproliferative and structure activity relationships of amaryllidaceae alkaloids

Cedrón, Juan C.; Ravelo, Ángel G.; León, Leticia G.; Padrón, José M.; Estévez-Braun, Ana · urn:issn:1420-3049 (2015) · DOI: 10.3390/molecules200813854

Resumen

The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.

Instituciones: Universidad de Ingeniería y Tecnología