Anti-inflammatory, immunomodulatory and antioxidant potential of bioactive components of mango waste in laying hens

Paredes M.; Tafur L.; Cáceres R. · Revista de Investigaciones Veterinarias del Peru (2026) · DOI: 10.15381/rivep.v37i1.32901

Resumen

The study aimed to evaluate the effectiveness of dietary supplementation with bioactive compounds from mango residues (CBRM) on intestinal morphometry, immune response, and stress status in laying hens. A total of 120 Novogen Brown hens, 30 weeks old, were randomly assigned to four groups fed a basal diet and supplemented with CBRM at levels of 0, 100, 200, and 300 mg/kg for 12 weeks. CBRM supplementation resulted in a significant increase in villus height and a higher villus height/crypt depth ratio in the duodenum, as well as an increase in white blood cell counts (eosinophils, lymphocytes, basophils, and monocytes; p<0.05) in the supplemented groups. A decrease in the heterophil/lymphocyte ratio was observed in treated groups (p<0.05). Furthermore, the 300 mg/kg group demonstrated a higher serum superoxide dismutase concentration. The 200 and 300 mg/kg groups showed improved antioxidant capacity and immune function by decreasing malondialdehyde levels and increasing serum glutathione peroxidase content (p<0.05). Antibody titres against infectious bronchitis virus were higher in the 300 mg/kg group (p<0.05). These findings suggest that dietary supplementation with CBRM improves serum antioxidant and immunological parameters, as well as gut health in laying hens. The 200 and 300 mg/kg doses of CBRM were identified as the optimal levels for these improvements. © Los autores. Este artículo es publicado por la Rev Inv Vet Perú de la Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos.

Instituciones: Universidad Nacional de Cajamarca