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Analysis of scientific production on asthma – COPD overlap syndrome.

Perleche J.J.G.; Santos M.N.L.; Solórzano F.O.G. · Revista Alergia Mexico (2026) · DOI: 10.29262/ram.v73i1.1566

Resumen

BACKGROUND: Asthma–COPD overlap syndrome (ACO) is characterized by features of both asthma and COPD and is associated with a higher risk of hospital admissions. While several studies have analyzed the scientific production on asthma and COPD separately, little is known about the state of research on the overlap syndrome. OBJECTIVE: To analyze the scientific output on asthma–COPD overlap (ACO). METHODOLOGY: A bibliometric study was conducted using Scopus and Web of Science, including original articles published up to 2024. Indicators of productivity, collaboration, and impact were analyzed with the bibliometrix package in RStudio. RESULTS: A total of 436 articles on ACO were identified. The first publication appeared in 2005, and since 2013 the scientific output has grown markedly, with an annual growth rate of 8.38%. The most productive countries were South Korea (n = 330), the United States (n = 329), and China (n = 312). The thematic analysis of research on ACO showed that the main areas studied are diagnosis and vulnerable populations, as well as the epidemiology and pathophysiology of the disease, while the treatment area remains under development, particularly regarding the study of monoclonal antibodies. CONCLUSION: The analysis of scientific production on ACO reveals that, despite the sustained increase in research, significant gaps persist regarding therapeutic strategies. Furthermore, research remains limited in several countries with a high disease burden; mapping these areas and regions will be essential to foster the generation of local evidence to guide clinical and public health decision-making. Copyright (c) 2026 Revista Alergia México. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License https://creativecommons.org/licenses/by-nc/4.0/.

Instituciones: Universidad Científica del Sur