Aggressive plurihormonal pituitary neuroendocrine tumor

Manrique G.M.; Del Pilar Rafael Robles L.; Flores M.S.M. · Anales de la Facultad de Medicina (2024) · DOI: 10.15381/anales.v85i2.27613

Resumen

We present the case of a 23-year-old male patient who developed symptoms of hyperthyroidism since he was 16 years old. At the age of 17, he presented symptoms due to excess growth hormone. Magnetic resonance imaging of the pituitary gland revealed a pituitary adenoma measuring 7 cm x 8 cm x 5 cm. The patient received surgical treatment with postoperative findings of plurihormonal adenoma with components of somatotropic, lactotrope, and thyrotrophic adenoma. Neuroendocrine tumors of the pituitary can present biomarkers of aggressiveness that can make them refractory, as in the case presented. In the future, the detection of mutations in transcription factors as the origin of uni- or plurihormonal excess production may lead to timely diagnosis and treatment.