Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of

Emily Sempou; Emiliano Biasini; Alejandro Pinzon-Olejua; David-A. Harris; George Edward Málaga Trillo

doi:10.1186/s13024-016-0076-5

Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of

Sempou, Emily; Biasini, Emiliano; Pinzon-Olejua, Alejandro; Harris, David-A.; Málaga Trillo, George Edward · urn:issn:1750-1326 (2016) · DOI: 10.1186/s13024-016-0076-5

Resumen

BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals control cell-cell adhesion via a tyrosine phosphorylation-dependent mechanism. RESULTS: Here we report that the Src family kinases (SFKs) Fyn and Yes act downstream of PrP-1 to prevent the endocytosis and degradation of

Instituciones: Universidad Peruana Cayetano Heredia